Alginate-coated quaternized chitosan nanoparticles for oral delivery of insulin
نویسندگان
چکیده
منابع مشابه
Preparation and Characterization of Quaternized Chitosan Coated Alginate Microspheres for Blue Dextran Delivery
In this study, 2-[(Acryloyloxy)ethyl]trimethylammonium chloride was graft polymerized onto chitosan (CS) to form quaternary ammonium CS (QAC) by using ammonium persulfate as a redox initiator. Alginate (ALG) microspheres loaded with a water-soluble macromolecular model drug, blue dextran (BD), were obtained by corporation of coaxial gas-flow method and ionic gelation process. CS and QAC were th...
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BACKGROUND Absorption of antigens onto chitosan microparticles via electrostatic interaction is a common and relatively mild process suitable for mucosal vaccine. In order to increase the stability of antigens and prevent an immediate desorption of antigens from chitosan carriers in gastrointestinal tract, coating onto BSA loaded chitosan microparticles with sodium alginate was performed by lay...
متن کاملNanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats
This study aimed to prepare nanoemulsions coated with alginate/chitosan for oral insulin delivery. Uncoated nanoemulsions were prepared by homogenization of a water in oil in water (w/o/w) multiple emulsion that was composed of Labrafac(®) CC, phospholipid, Span™ 80 and Cremorphor(®) EL. Coating of the nanoemulsions was achieved based on polyelectrolyte cross-linking, with sequential addition o...
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In spite of the prevalence of subcutaneous injections for insulin administration, there are several concerns associated with this mode of administration including injection anxiety, pain, cost, infection, and as a result an overall decrease in patient compliance (Khafagy 2007). This has prompted researchers to search for alternative delivery methods including transdermal, nasal, pulmonary, rect...
متن کاملSelf-assembled lecithin/chitosan nanoparticles for oral insulin delivery: preparation and functional evaluation
PURPOSE Here, we investigated the formation and functional properties of self-assembled lecithin/chitosan nanoparticles (L/C NPs) loaded with insulin following insulin-phospholipid complex preparation, with the aim of developing a method for oral insulin delivery. METHODS Using a modified solvent-injection method, insulin-loaded L/C NPs were obtained by combining insulin-phospholipid complexe...
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ژورنال
عنوان ژورنال: Journal of Chinese Pharmaceutical Sciences
سال: 2014
ISSN: 1003-1057
DOI: 10.5246/jcps.2014.12.104